Explore BrainMass

Somatic recombination

This content was STOLEN from BrainMass.com - View the original, and get the already-completed solution here!

Here is the problem:


Go there and click through to the "Molecular Movie" on "somatic recombination."

Run the animation.

The animation depicts the human lambda locus.....so there are some similarities and differences from the mouse heavy and light chain loci that we used during the live session.

In your response, compare and contrast the similarities and differences between the human lambda and murine kappa loci in terms of organization and mechanisms active in generating diversity.

© BrainMass Inc. brainmass.com October 24, 2018, 9:02 pm ad1c9bdddf

Solution Preview

Antibody molecules consist of two identical heavy and two identical light chains. In humans, two types of light chains, kappa and lambda, are found, but each individual B-cell expresses only one type either kappa or lambda. Functional genes coding for heavy and light chain are formed by DNA rearrangements during maturation of B-lymphocytes. Immunoglobin genes seem to follow a developmentally regulated hierarchy of rearrangements. A functional rearrangement in a heavy chain ...

See Also This Related BrainMass Solution

Genetics and cell biology questions, including meisosis I & II and chromsomal mutations.

1. What is the state of the DNA at the end of meiosis I? What about at the end of meiosis II?
2. Why are chromosomes important?
3. How are Meiosis I and Meiosis II different?
4. Name two ways meiosis contributes to genetic recombination.
5. Why do you use non-sister chromatids to demonstrate crossing over?
6. Why is it necessary to reduce the chromosome number of gametes, but not other cells of an organism?
7. If humans have 46 chromosomes in each of their body cells, determine how many chromosomes you would expect to find in the following:

Daughter cell from mitosis_________________
Daughter cell from Meiosis II_______________

8. Investigate a disease that is caused by chromosomal mutations. When does the mutation occur? What chromosome is affected? What are the consequences?

View Full Posting Details