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Somatic recombination

Here is the problem:


Go there and click through to the "Molecular Movie" on "somatic recombination."

Run the animation.

The animation depicts the human lambda locus.....so there are some similarities and differences from the mouse heavy and light chain loci that we used during the live session.

In your response, compare and contrast the similarities and differences between the human lambda and murine kappa loci in terms of organization and mechanisms active in generating diversity.

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Solution Preview

Antibody molecules consist of two identical heavy and two identical light chains. In humans, two types of light chains, kappa and lambda, are found, but each individual B-cell expresses only one type either kappa or lambda. Functional genes coding for heavy and light chain are formed by DNA rearrangements during maturation of B-lymphocytes. Immunoglobin genes seem to follow a developmentally regulated hierarchy of rearrangements. A functional rearrangement in a heavy chain ...