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Why large recomination frequency values less accurate?

Explain why large recombination frequency values are less accurate measures of map distance than smaller ones

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Recombination frequency of genes is used to estimate their physical distance from each other. A normal event during the process of cell division in the creation of sex cells (meiosis) is the process of crossing over where pieces of identical chromosomes can switch places. The other concept we need to understand is independent assortment. This the idea the that genes will be separated into sex cells independent of each other. However this is not always the case since it is in fact the chromosomes that are independently assorted, not necessarily genes themselves. ...

Solution Summary

Discussion of what recombination frequency measures and how accuracy of measurement decreases as distance increases.

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