Diversity is very important in ensuring a sufficient immune response to accommodate the vast number of immune response. This solution describes in detail, with the aid of a diagram, how B cells generate diversity in the antibodies they produce.© BrainMass Inc. brainmass.com May 20, 2020, 6:22 pm ad1c9bdddf
Antibody diversity derives from the combination of several different factors. The antibody molecule consists of a constant region, a variable region and junction (J) regions. In the germline, these sections are encoded by different exons spread along the chromosome. As a B cell develops, these exons re-arrange to be juxtaposed to one another, forming an intact gene (see attached figure). In the mouse there are 200-500 variable regions from which to choose, and 4 different J regions, ...
This solution describes, with the aid of a diagram, how B lymphocytes are able to generate a very diverse pool of antibodies. The solution gives a detailed description of the mechanisms used to generate this diversity.