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Vaccines for Mild Diseases and, Cytoltic and Antibody Responses

What kind of vaccine (live, dead, whole, viral protein, etc) would be the best for a virus that causes a mild disease in individuals with a heavy cytolytic response and severe to individuals who produced a primarily antibody response? Ideas are generated.

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The object of your viral vaccine should be to induce a strong cytolytic response. Your goal should be to induce a strong cell-mediated response as oppose to the humoral (antibody response). The primary mediators of a cell-mediated response are the antigen-specific T cells (or cytotoxic T cells - CTLs). This is exactly the kind of vaccine researchers are currently trying to develop for HIV.

Although antibodies have an important role in containing the spread of a virus in the acute phases of infection, they are not usually able to eliminate the virus once infection has occurred - particularly if the virus is capable of entering the latent state. Once the infection is established cell-mediated immune mechanisms are the most important host defense.

Dead viral proteins tend to induce primarily an antibody response (see below). I will quickly go over the main types of vaccination possible which will hopefully set you in the right direction.

Whole vaccine: Whole virus vaccines can either be attenuated (avirulent) viruses or inactivated (killed) viruses. As you will see from my comparison below, the attenuated offers the ...

Solution Summary

Vaccine types are emphasized.