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Biochemistry: Liver Mitochondria Oxygen Uptake Inhibition

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1.

A drug impairs oxyegen consumption on liver mitochondria at a buffer of 7.4pH, Mg, and adp. It inhibits O2 uptake if isocitrate, 2-ketoglutarate and malate were substrates, but it will NOT is succinate is a substrate.

Where's the site of inhibiiton: ATP synthase, malate dehydrogenase, Complex I, II, or III

2.

What is the compound that's the oxidizing agent for Complex II of the respiratory chain?

3.

What is the enzyme of beta-oxidation that's analoguos to malate dehydrogenase RXN?

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Solution Summary

Liver mitochondria oxygen uptake inhibition is examined. The compound of oxidizing agent for Complex II of the respiratory chain.

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Biochemistry
1. A drug impairs oxygen consumption on liver mitochondria at a buffer of 7.4pH, Mg, and adp. It inhibits O2 uptake if isocitrate, 2-ketoglutarate and malate were substrates, but it will NOT if succinate is a substrate. Where's the site of inhibiiton: ATP synthase, malate dehydrogenase, Complex I, II, or III

Isocitrate, 2-ketoglutarate and malate are substrates of Dehydrogenases in the Krebs cycle that produce NADH as one of the products of oxidation reactions. The NADH is then funneled to the electron transport chain through ...

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