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Drugs' neurological effects on the brain

What are the specific neurological effects that drugs have on the brain? How is the brain affected physiologically by the presence of drugs?

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I just responded this to a similar question about how drugs affect the brain:

Drugs ABSOLUTELY affect behavior. They are chemicals. They work in the brain by tapping into the brain's communication system and interfering with the way nerve cells normally send, receive, and process information. Some drugs, such as marijuana and heroin, can activate neurons because their chemical structure mimics that of a natural neurotransmitter such as GABA or Acetylcholine. This similarity in structure "fools" receptors and allows the drugs to lock onto and activate the nerve cells. Although these drugs mimic brain chemicals, they don't activate nerve cells in the same way as a natural neurotransmitter, and they lead to abnormal messages ...

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specific neurological effects that drugs have on the brain