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    SARS virus and protein

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    1. Obtain the SARS virus genetic virus and gather info on proteins in that virus. Gather details on proteins made by this virus.

    Please submit the answer in doc or docx.

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    Solution Preview

    See the attached file.
    Severe Acute Respiratory Syndrome Coronavirus and Related Proteins
    On April 2003, the Centers for Disease Control and Prevention (CDC) announced that it had identified the genome what they thought to be the virus responsible for the global epidemic of severe acute respiratory syndrome or SARS. The virus belongs to the coronavirus family and forms its own group (CDC Media Relations, 2003, April 13). The lineage is as follows: Viruses → ssRNA positive-strand viruses, no DNA stage → Nidovirales → Coronaviridae → Coronavirinae → Betacoronavirus → Severe acute respiratory syndrome-related coronavirus (NCBI, n.d.)
    The single stranded ribonucleic acid (RNA) sequence described for the SARS coronavirus (SARS-CoV) has 29.7 kb nucleotides well within the boundaries of the coronaviruses 29,000 to 31,000 nucleotides (CDC Media Relations, 2003, April 13). The complete sequence can be seen at the genome bank of the National Center for Biotechnology Information (NCBI) under NCBI Reference Sequence: NC_004718.3
    The genomic organization of the coronaviruses has been established as nonstructural proteins encoded in the upstream open reading frames while the structural proteins are encoded by subgenomic mRNAs (Plant, Rakauskaite, Taylor, & Dinman, 2010). The frameshift-dependent downstream open reading frames (ORFs) encode enzymes involved in transcription and replication (Plant et al., 2010).
    Fourteen open reading frames have been identifies, 12 located at the 3' end genome (Pan, Peng, Gao, Li, Lu, Chen, Ishaq, Liu, DeDiego, Enjuanes, & Guo, 2008). ORF1a and ORF1b encode the viral replicase (Pan et al., 2010). The ORF1a-encoded polyprotein (pp1a) synthesizes nonstructural proteins (Plant et al., 2010). Plant, Rakauskaite, Taylor & Dinman (2010) stated that the −1 PRF signal is located at the 3′ end of ORF1a and sends ...

    Solution Summary

    The solution is an attached 4-page word document that describes the SARS virus and the proteins made by the virus. It includes a page with references that includes an article from von Brunn about the interactions of the proteins.