Viral Replication and Retroviral
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Describe the process of viral replication; discuss both normal and retroviruses, and comment on the implications of this process for genetic engineering.
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Solution Summary
Do you get confused when dealing with viral replication? Are you curious how retroviruses work? In this solution, we consider two phenomena, typical (adenoviral) and retroviral replication. What makes them tick? How can they make more of themselves? You will receive a step-by-step guide to the process, and you will see how retroviruses are able to be sneaky little guys, with a brief introduction into how we use them in molecular biology to make changes and even potentially cure diseases!
3 sources are included for your edification.
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Because viruses do not have any cellular machinery, they have adapted by taking over the DNA and protein machines of the cells they infect, be they bacteria, yeast, or even as high as human cells.
There are actually several types of viruses, including retroviruses, bacteriophages, lentiviruses, and adenoviruses. By "normal," I believe you mean the adenovirus. I will describe its replication process, step-by-step:
1) The virus attaches to the cell and becomes internalized via endocytosis
2) The viral glycoprotein fuses with its vesicle, promoting the release of its components (typically the DNA and viral polymerases)
3) The viral polymerases make RNA from the DNA
4) The RNA encodes for various pieces of the virus, such as the capsid glycoprotein, which is manufactured by the protein synthesis ...
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