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    A new drug was found to decrease Hepatitis B virus. The drug is an analogue of one of the nucleic acid bases of DNA and probably works by being incorporated into the virus and disrupting viral genes during viral DNA replication. However, patients in a clinical trial of the drug began to experience drastic overproduction of lactic acid and liver failure leading to death. What is the most likely explanation for the problem? Why did fermentation occur?

    © BrainMass Inc. brainmass.com December 24, 2021, 4:52 pm ad1c9bdddf
    https://brainmass.com/biology/metabolism/lactic-acid-production-12605

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    1. A new drug was found to decrease Hepatitis B virus. The drug is an analogue of one of the nucleic acid bases of DNA and probably works by being incorporated into the virus and disrupting viral genes during viral DNA replication. However, patients in a clinical trial of the drug began to experience drastic overproduction of lactic acid and liver failure leading to death. What is the most likely explanation for the problem? Why did fermentation occur?

    First, the overproduction of lactic acid is evidence that fermentation is occurring on a large scale. Knowing that the drug can interfere with DNA replication, it makes sense to conclude that it has interfered with mitochondrial DNA and affected normal ATP production.

    If the mitochondria's ability to produce ATP were disrupted, the ATP would have to be produced outside the mitochondria, by fermentation taking place in the cytosol. Though it is normal for the body to use fermentation, especially by muscle cells during hard exercise, fermentation is a temporary response that cannot be sustained in humans.

    In the case of patients in this clinical trial, ongoing exposure to the drug would disrupt mitochondrial DNA as use continued, rendering more mitochondria unable to produce ATP. Lactic acid production as a by-product of fermentation would continue, and eventually overwhelm the liver.

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    This content was COPIED from BrainMass.com - View the original, and get the already-completed solution here!

    © BrainMass Inc. brainmass.com December 24, 2021, 4:52 pm ad1c9bdddf>
    https://brainmass.com/biology/metabolism/lactic-acid-production-12605

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