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Elements of Antiviral Immunity and Viral Evasion

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Describe the elements of humoral and cellular immunity that are involved in immune responses to viral infections.

What mechanisms have infectious agents evolved to defeat these elements?

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Solution Summary

This solution details the roles played by the cellular and humoral immune responses to virus infections. It also details strategies viruses have evolved to evade these immune responses.

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Humoral immunity is the element of immunity that is present in the serum, and consists of immunoglobulins (antibodies). Antibodies are produced by B lymphocytes, and they exist in a soluble form in blood serum. Their function is to bind and inhibit infectious agents or secreted toxins. Antibody binding can neutralize the ability of a pathogen to infect, or prevent toxins from killing cells. Binding of antibody to the surface of a pathogen can also activate the complement system, which can form pores in the outer membrane and kill the organism.

Cellular immunity consists of T lymphocytes. Rather than recognizing a protein from an infectious agent directly, these cells only recognize proteins that have been partly degraded by cells of the host, peptides from which are presented on MHC molecules ...

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