Discuss different models for DNA replication that were considered by early researchers. Explain why they settled on the current model for DNA replication. Describe this model in detail and interpret the significance of helicases, gyrases, RNA primer, DNA polymerase, Okazaki fragments, and DNA ligase.
In the 1950's Watson and Crick showed that DNA was a double helix. It is composed of two strands of DNA wrapped around each other in a spiral fashion. However people were not able to understand how such a structure replicated. There were two explanations for how DNA replicated. One is called the conservative and the other semi conservative models. Both models believe that the two strands of DNA separated in order for replication to take place. However in the conservative version, it was believed that the two parents' strands found each other and formed a helix after the strands were replicated. Same for the daughter strands. In the semi conservative model, the resulting two DNA helixes each had one strand from the parent and the other from the daughter strand. Finally the Meselson-Stahl experiment showed that ...
The solution discusses the different models for DNA replication that were considered by early researchers.