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Genetics of cancer

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5. Explain what proto-oncogenes are and describe their role as intracellular signal transducers and transcription factors.

6. Explain the notion that cancer is seen a genetic disease and that the predisposition of cancer can be inherited.

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The solution provides paragraphs and web references answering two short questions on the genetics of cancer.

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5. Proto-oncogenes are genes that are normally active during development to promote cell division. These genes are important but highly regulated. When they are activated inappropriately they become oncogene and promote the growth of cells unchecked resulting in tumors. Their typical cellular functions are as intracellular signal transducers, like ras or beta-catenine, or as transcription factors, like Jun and Myc. Intracellular signal transducers ...

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