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During DNA replication, the base that is present can be shifted through what's known as a wobble. Basically, one base is subsituted for another. In the case of the Mc1r protein, a single nucleotide exchange can occur.
The codon for histidine is CAT (cytosine adenosine thymine). This is changed to the codon to histidine, TAT (thymine adenosine thymine), so a ...
This solution includes a description of how defects in replication can cause amino acid substitutions within proteins. Additionally, this solution includes reference sources for further research on the topic.