Compartments in the secretory pathway
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Please provide some information about the relationships between the intra -cellular compartments involved in the secretory and endocytic pathways, also please distinguish between co-translational and post translational protein targeting.
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Solution Summary
In this solution we consider various cellular compartments found in the secretory and endocytic pathways, paying special attention to how these structures are found in common to both of them. A picture is included that lists the big players of endocytosis and secretion.
In addition, a description of co-translational vs. post-translational processing of proteins is given, specifically the means by which proteins can be targeted to their specific destinations.
Solution Preview
First of all, there is a useful picture taken from molecular biology of the cell that illustrates very clearly what I am going to explain. It contains a little more information than is necessary, but it's a good figure!
The compartments in trafficking can differ widely whether we're secreting or endocytosing components. When something is to be degraded, the endosomes are the common endpoints. If we're moving a poorly-folded protein, for example, the golgi will transfer to the late endosome and to the lysosome to be degraded. This is a common fate for proteins that need to be dealt with! The golgi is sort of the lynchpin for both secretory and endocytic pathways. It generates the secretory vesicles needed to move components, but it can also lead proteins BACK to the endoplasmic reticulum (or ...
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