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    characteristics of the peptide-binding cleft and peptides bound by class I and class II MHC molecules

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    Describe the characteristics of the peptide-binding cleft and peptides bound by class I and class II MHC molecules.

    © BrainMass Inc. brainmass.com October 9, 2019, 11:44 pm ad1c9bdddf
    https://brainmass.com/biology/human-biology/characteristics-peptide-binding-cleft-peptides-bound-266423

    Solution Preview

    The peptide-binding cleft of both class I and class II molecules is that the floor of eight antiparallel β strands and sides of antiparallel α helices.

    ? The peptide-binding cleft is located on the top surface of the class I MHC molecule, and binds to a peptide of 8-10 amino acids.
    ? In order to achieve the fully folded conformation of class I molecule, the interaction of β2 microglobulin and a peptide with the class I α chain is required.
    ? They are expressed in all nucleated cells and present antigen fragments to the cytotoxic T-cells. These peptides are derived from endogenous intracellular proteins that are digested in the cytosol.
    ? Each type of MHC class I molecule binds a unique set of peptides. The peptides are 8-10 amino acids in length, and specific amino acids are ...

    Solution Summary

    Characteristics of the peptide-binding cleft and peptides bound by class I and class II MHC molecules are featured.

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