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characteristics of the peptide-binding cleft and peptides bound by class I and class II MHC molecules

Describe the characteristics of the peptide-binding cleft and peptides bound by class I and class II MHC molecules.

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The peptide-binding cleft of both class I and class II molecules is that the floor of eight antiparallel β strands and sides of antiparallel α helices.

? The peptide-binding cleft is located on the top surface of the class I MHC molecule, and binds to a peptide of 8-10 amino acids.
? In order to achieve the fully folded conformation of class I molecule, the interaction of β2 microglobulin and a peptide with the class I α chain is required.
? They are expressed in all nucleated cells and present antigen fragments to the cytotoxic T-cells. These peptides are derived from endogenous intracellular proteins that are digested in the cytosol.
? Each type of MHC class I molecule binds a unique set of peptides. The peptides are 8-10 amino acids in length, and specific amino acids are ...

Solution Summary

Characteristics of the peptide-binding cleft and peptides bound by class I and class II MHC molecules are featured.

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