# Transport of pilocarpine across the corneal membrane

I am trying to work through calculations to obtain the delta H and delta S in the example 3 - 14 on page 71 of Martin's Physical Pharmacy. A set of data (log Ka v. 1/T x 10^3) is plotted and the linear form of the van't hoff equation should be used to calculate delta H and delta S. The equation in this form is:

ln K = -(delta H/R)1/T + delta S/R or y = mx + b where: delta H/R = m and delta S/R = b.

In the study of the transport of pilocarpine across the corneal membrane of the eye, Mitra and Mikkelson presented a van't Hoff.

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I am trying to work through calculations to obtain the delta H and delta S in the example 3 - 14 on page 71 of Martin's Physical Pharmacy. A set of data (log Ka v. 1/T x 10^3) is plotted and the linear form of the van't hoff equation should be used to calculate delta H and delta S. The equation in this form is:

ln K = -(delta H/R)1/T + delta S/R or y = mx + b ...

#### Solution Summary

The solution provides a detailed and step-by-step explanation for the problem that discusses transporting pilocarpine across the corneal membrane. It also provides the Excel calculations required.