Regardless of bloodtype what is the problem if the Mother is Rh- with an Rh+ baby? 1st baby, and subsequent babies if not addressed? What happens and how?
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I'll answer the blood type question first.
As you know, the Rh factor is an antigen found on the surface of RBCs (red blood cells). People who have Rh antigens are known as Rh+ and those without the Rh antigens are known as Rh-.
Normally, blood plasma does not contain anti-Rh antibodies. However, if an Rh- individual receives Rh+ blood, the immune system starts making anti-Rh antibodies (with, of course, a built in molecular memory system for later such assaults). If there is a second transfusion of Rh+ blood, the previously formed anti-Rh antibodies will attack the donor RBCs and cause hemolysis. This can cause a severe problem to say the least. It could lead to massive anemia and shock.
So, with an Rh- mother carrying an Rh+ child, there is no problem with the first child. However, sometimes, during that birth of the first child, some blood from the child gets into the mother's bloodstream. This could happen if small amounts of fetal blood passed through the placenta. As a ...
The Rh factor and its effect on pregnancy is explained.