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    Independent Signaling in Immunology

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    This is for an graduate immunology class. The question is:

    1) Can someone explain why the MyD88 independant stimulation of TLR4 has been suggested?

    Any other little details about MyD88 (it is a hard topic to find) would be greatly appreciated!

    Thank you.

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    https://brainmass.com/biology/human-anatomy-and-physiology/independent-signaling-immunology-58000

    Solution Preview

    Please view the doc. file attached.
    With best wishes

    This is for an graduate immunology class. The question is:

    1) Can someone explain why the MyD88 independant stimulation of TLR4 has been suggested?

    Any other little details about MyD88 (it is a hard topic to find) would be greatly appreciated!

    Thank you.

    Solution:

    The signaling of TLR [Toll like receptors] via myeloid receptor protein MyD88 as mediators has been studied in mice models against gram negative bacterial infection in which the signaling pathways are MyD88 dependent. Read the 2nd paper, its available free in pubmed.

    However studies on Streptococcus mutants with ...

    Solution Summary

    Independent signaling in immunology are determined.

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