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Types of mutations that could occur in a proto-oncogene gene

The following list are several types of mutations that could occur in a proto-oncogene or a tumor-suppressor gene. Some of these mutations may increase the rate of progression through the cell cycle (Thus promoting cancer), whereas others would either decrease the rate or have no effect.

For each of the below scenarios, write "increase," "decrease," or "no effect" to describe how the mutation in the proto-oncogene or tumor-suppressor gene would be expected to affect the rate of cell division and briefly explain why you choose that answer.

a. Deletion of the coding region for a proto-oncogene
b. Deletion of an enhancer located upstream of a tumor-suppressor gene
c. Translocation of the a proto-oncogene coding region near a strong enhancer
d. A retrovirus inserts into an exon of a tumor suppressor gene
e. A proto-oncogene is translocated to a heterochromatic region of the genome

Solution Preview

Thanks for letting me work on your post. Here is my explanation:

a) In this case, it becomes proto-oncogene null and therefore it will have no ...

Solution Summary

The types of mutations that could occur in a proto-oncogene gene. are determined.

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