Explore BrainMass
Share

Structural chromosomal abnormalities causing pregnancy loss.

This content was STOLEN from BrainMass.com - View the original, and get the already-completed solution here!

A female has suffered five consecutive miscarriages.Cytological study of her peripheral blood revealed 46,XX inv(1) (p32 q34) in all her cells and inversion (9) (p12 q12) in 30% of the studied cells. It is likely that the chromosome 1 abnormality is the cause of the woman's recurrent miscarriages.

a) Explain in words the nature of the woman's chromosome 1 abnormality.

b) Find an ideogram of human chromosome 1 and DRAW with key landmarks, the woman's chromosomes 1, paired during oogenesis' first meiotic prophase. LABEL key landmarks.

c) Suppose in 70% of meiosis there is a crossover somewhere in the region between bands p32 and q34. DRAW the gametic chromosomes 1 that would result from meiosis in which a single crossover occurred within band q 1.1.

d) What fraction of the gametes are likely to give rise to normal development, if the chromosome 1 abnormality is the only cause of gametic/zygotic non-viability?

© BrainMass Inc. brainmass.com October 25, 2018, 6:09 am ad1c9bdddf
https://brainmass.com/biology/dna-chromosomes-and-genomes/structural-chromosomal-abnormalities-causing-pregnancy-loss-449986

Solution Preview

a) Explain in words the nature of the woman's chromosome 1 abnormality.

The sequence between p32 and q34 on chromosome 1 is inverted.

b) Find an ideogram of human chromosome 1 and DRAW with key landmarks, the woman's chromosomes 1, paired during oogenesis's first meiotic prophase.LABEL key landmarks.

See attached file.

c) Suppose in 70% of ...

Solution Summary

Short paragraph answers with needed diagrams and web references.

$2.19
See Also This Related BrainMass Solution

Help needed

AP Bio: Preparation of Human Chromosome Spreads- Kit 4

1. Specify the location and function of the centromere.

2. a) Name the three types of chromosomes found in human cells based on the location of the centromere.
b) Which type is not found in human cells?

3. Why is it necessary to expose the cells to hypotonic solution when preparing cells for karyotyping?

4. Define the role of histones in the chromosomes.

5. Explain the difference between an aneuploid cell and a diploid cell.

6. During which stage of mitosis are the chromosomes in their most condensed state and thus best suited for karyotyping?

7. Describe the role of amniocentesis?

8. What test gives results of chromosomal abnormalities after 8 weeks of pregnancy?

9. a) What chromosome abnormality is caused by an extra autosome (trisomy)?
b) What chromosome abnormality is caused by an extra sex chromosome?
c) What chromosome abnormality is caused by a missing sex chromosome (monosomy)?

View Full Posting Details