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Experimental Design: Relationship Between mtdna and ageing

I have not clue where to start on this or how to go about it.

Apart from its essential role in cellular respiration, the mitochondrion is thought to be implicated in a variety disease states as well as the process of ageing. The mitochondrion contains its own circular DNA molecules (termed mtDNA) which largely encodes for proteins localized to the mitochondrion itself. Please provide a hypotheses and suggest an experiment to test the relationship between mtDNA and human ageing. Propose a direction for research and drug development for targeting mtDNA to combat the ageing process.

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