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Cytogenetics (Theoretical) Project

Would it be possible to investigate possible homology between the Y chromosome on an animal (eg; platypus) and the Y chromosome on a human - using FISH (fluorescent in situ hybridization)?

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It would be possible to investigate chromosome homology this way, but I don't think it would be a very effective method for doing this. FISH is normally used to determine whether a specific sequence is present or absent. The FISH probe is designed to complement a specific sequence of interest, and then binding of the probe and subsequent fluorescence tells us that the sequence is present. It might be possible to design ...