It would be possible to investigate chromosome homology this way, but I don't think it would be a very effective method for doing this. FISH is normally used to determine whether a specific sequence is present or absent. The FISH probe is designed to complement a specific sequence of interest, and then binding of the probe and subsequent fluorescence tells us that the sequence is present. It might be possible to design ...
The expert investigates the possible homology between Y chromosomes on an animal and Y chromosomes on a human. Fluorescent in SITU hybridization is determined.