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Water solubility of secondary messengers

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Is it true that all small intracellular mediators (second messengers) are water-soluble and pass freely through the cytosol? Why?

I know this is true, but why is it true?

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Solution Summary

The expert examines water solubility of secondary messengers. Water-solubility of passing through cytosol are determined.

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Well, all of the cytosolic second messengers that I can think of off the top of my head are certainly water-soluble and pass freely through the cytosol, e.g. cyclic AMP, Ca ions, inositol triphosphate, etc.

Why would this be ...

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