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Birth Defects and Pedigree

Birth Defects and Pedigree

Jane Marlow is pregnant with her first baby. Along with explaining about genetic disorders, also explain to Marlow about certain habits of the mother that affect the growth of the fetus. Use the following questions as guidelines:

What are the adverse effects of using teratogens during pregnancy?

If a woman drinks or uses drugs during her pregnancy and it harms her growing fetus, do you think she should be held legally responsible for her actions? Why or why not?

Select a disease that exhibits pleiotropy or incomplete penetrance. How does the disease exhibit these characteristics? Can the severity of the disease be affected by families having these traits? If so, how? If not, why not?

Using Mendel's laws, describe the phenotypic and genotypic ratios for the F2 generation if pea plants with restricted yellow pods are crossed with true-breeding inflated green pods in the original cross and then the F1 generation is crossed.

Do you agree or disagree that cis-regulatory and coding mutations make qualitatively different contributions to the phenotypic evolution of species? Why or why not?

Solution Preview

The evolutionary significance of cis-regulatory mutations. Academic Journal (English) By: Wray GA, Nature Reviews. Genetics [Nat Rev Genet], ISSN: 1471-0056, 2007 Mar; Vol. 8 (3), pp. 206-16

Jane Marlow is pregnant with her first baby. Along with explaining about genetic disorders, also explain to Marlow about certain habits of the mother that affect the growth of the fetus. Use the following questions as guidelines:

What are the adverse effects of using teratogens during pregnancy?

Adverse effects emanating from using teratogens are developmental defects that are produced in humans, which may result in Mendelian or chromosomal genetic defects that are caused by potentially almost any drug that is used by mothers during their pregnancy, which could be deleterious to the fetus. This causes an anatomic defect that is teratogenic.

If a woman drinks or uses drugs during her pregnancy and it harms her growing fetus, do you think she should be held legally responsible for her actions? Why or why not?

Yes, the responsibility to ensure that a baby isn't born addicted to drugs is the primary responsibility of the mother. ...

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