HIV Resistance and Therapy
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1. ALLELIC VARIATION IN PEOPLE HAS ALLOWED SOME PEOPLE TO BE EXPOSED TO HIV MANY TIMES WITH OUT BECOMING INFECTED AND PROGRESSING TO AIDS. EXPLAIN THE MOLECULAR BASIS FOR THIS RESISTANCE.
2.THERE ARE 2 KINDS OF REVERSE TRANSCRIPTASE INHIBITORS, HOW DOES THE INHIBITOR FUNCTION TO PREVENT REVERSE TRANSCRIPTION OF THE VIRAL RNA INTO DNA?
3. GIVE AN EXAMPLE OF A DRUG TARGETED TO ANOTHER PHASE OF THE VIRUS LIFE CYCLE, AND BRIEFLY DESCRIBE HOW IT FUNCTIONS.
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Solution Summary
This solution describes how rare individuals are resistant to HIV and can be exposed to the virus multiple times without becoming infected. It also describes the types of drugs used to inhibit HIV reverse transcriptase, and drugs targeted to inhibit other phases of the virus life cycle.
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1) Allelic variation can lead to different sequences in the CCR5 gene, one of the receptors used by HIV to infect human cells. While the virus binds well to the most common isoforms of CCR5, some individuals have mutations that prevent HIV from binding well, and are therefore much less likely to be ...
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