Explore BrainMass
Share

Explore BrainMass

    Mouse strain nomenclature

    This content was COPIED from BrainMass.com - View the original, and get the already-completed solution here!

    Using the following examples, describe the components of mouse strain nomenclature and their significance.

    a) FVB.129P2-Apoe<tm1Unc>
    b) C57BL/6-Tg(CAG-cre)13Miya
    c) B6.Cg-Hprt<tm319(CAG-cre)Ems>

    © BrainMass Inc. brainmass.com October 10, 2019, 4:50 am ad1c9bdddf
    https://brainmass.com/biology/genetics/mouse-strain-nomenclature-479819

    Solution Preview

    a) FVB.129P2-Apoe<tm1Unc>

    The period (.) indicates a congenic strain (backcrossed onto a single background for 5 or more generations). The first strain designation (FVB) indicates the background that the allele was backcrossed onto. The second strain designation (129P2) is the background the allele was generated in. This is the strain of the ES cells used. The dash (-) separates the strain background and allele components.

    Apoe is the symbol for the gene. The information within the superscript represents the allele. tm ...

    Solution Summary

    This solution provides a detailed description explaining the strain and allele nomenclature for the examples given. Web references listed.

    $2.19