Indirect Transcription Factor Activation
Not what you're looking for?
What exactly are SMAD transcription factors and how do they regulate transcription? (can you please outline their involvement in the pathway in a simply manner which I can then use as a basis for my essay. Thank you!
Purchase this Solution
Solution Summary
Transcription factors can be activated either directly or indirectly. This response examines indirect transcription factor activation through the TGF beta and SMAD signalling pathway. Individual steps of the pathway are discussed. A brief overview of the biological significance of the pathway in human disease is addressed.
Solution Preview
1) What is a SMAD?
A SMAD is a protein that is a transcription factor. Transcription factors regulate gene expression in the nucleus when they are activated. Transcription factors can be activated two ways: through direct or indirect activation. SMADS are activated indirectly by an extracellular receptor.
Review of transcription factor activation:
SMADs are activated indirectly. Indirect activation involves the binding of an extracellular ligand to an extracellular receptor. Activation of the ...
Purchase this Solution
Free BrainMass Quizzes
The Transfer of Energy in an Ecosystem
This quiz will assess your knowledge of how energy is transferred in an ecosystem and the different levels of trophic organization.
Nerves and the Nervous System
This quiz will assess your knowledge of the nervous system and how nerves send signals around the body.
Do You Know Your Macromolecules?
This quiz will assess your knowledge of the macromolecules that are important to living things.
Breastfeeding Basics
How much do you know about breastfeeding? Find out with this quiz!
Pregnancy Knowledge
How much do you know about being pregnant? Test your Pregnancy IQ with this quiz!