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Physical and metabolic contraints

I need guideness on the physical and metabolic constraints limit cells size? And how an enormous cell encounter and adapations would help large cells survive?

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One of the main reasons cells are small is due to the surface area/volume constraint.

Consider a ball. As it expands, its surface area expands at a slower rate than its volume. (You can check out the mathematics of that by looking at the volume of a sphere versus the surface area of a sphere.) In other words, as it expands its surface area/volume ratio gets smaller and smaller. Therefore, to have the largest surface area/volume ratio, the cells should be as small ...