1. A type of cell called a lymphocyte makes proteins that are exported from the cell. You can track the path of these proteins within the cell from production through export by labeling them with radioactive isotopes. Identify which of the following structures would be radioactively labeled in your experiment, listing them in the order in which they would be labeled: chloroplasts, Golgi apparatus, plasma membrane, smooth ER, rough ER, nucleus, mitochondria.
2. Imagine that you are a pediatrician and one of your patients is a newborn who may have a lysosomal storage disease. You remove some cells from the patient and examine them under the microscope. What would you expect to see? Design a series of tests that could reveal whether the patient is indeed suffering from a lysosomal storage disease.
3. What is the primary difference between passive and active transport in terms of concentration gradients?
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1. Proteins destined for secretion or incorporation into the ER, Golgi apparatus, lysosomes, or plasma membrane are initially targeted to the ER. In mammalian cells, most proteins are transferred into the ER while they are being translated on membrane-bound ribosomes. In contrast, proteins destined to remain ...
This solution provides some explanation for some basic questions in cell biology, such as protein synthesis pathway in different cell organelles, lysosomal storage disease, active transport and passive transport.