# Needleman-Wuncsh Dynamic Programming Method

Using the document attached, use the Needleman-Wunsch dynamic programming method to align the following pair of sequences.

(see attached)

Use the unitary scoring method to score the initial alignment matrix. Write the appropriate score into each square in the matrix below.

(see attached)

Use the Needleman-Wunsch dynamic programming based scoring algorithm to calculate the new sore for the alignment matrix. Write the appropriate score into each square in the matrix below.

(see attached)

Determine the alignment of these two sequences by retracing the path (traceback) and write the alignment and its score below.

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#### Solution Preview

Hi,

I have posted the detailed response to the question of the Needleman-Wuncsh dynammic programming as an excel file attachment as well as below.

Please open the excel file attachment to view it.

Use the Needleman-Wunsch dynamic programming method to align the following pair of sequences. (1)

S1: ATGGAT

S2: AGGCAT

Use a Scoring method: exact match = 1

...

#### Solution Summary

The Needleman-Wunsch dynamic programming is based on scoring algorithm to calculate the new score for the alignment matrix.