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    Pka Histidine Protein Active Site

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    The pKA of histidine in a protein active site where it is next to an aspartate or glutamate would be____________ the pKa of free histidine solution

    higher, lower, no different

    Is it higher??

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    https://brainmass.com/biology/biological-chemistry/pka-histidine-protein-active-site-143044

    Solution Preview

    To answer this question, we need to know what pKa means.

    pKa = -log Ka

    So, what does that tell us? What is Ka? That is the dissociation or ionization constant for an acid.

    HA + H2O <------> A- + H3O+

    Ka = [A-][H3O+]/[HA]

    Therefore, the more that the acid dissociates in water, the larger the Ka. The Ka is a measure of the degree of ionization of an acid in water. A ...

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