Explore BrainMass

Explore BrainMass

    Pka Histidine Protein Active Site

    Not what you're looking for? Search our solutions OR ask your own Custom question.

    This content was COPIED from BrainMass.com - View the original, and get the already-completed solution here!

    The pKA of histidine in a protein active site where it is next to an aspartate or glutamate would be____________ the pKa of free histidine solution

    higher, lower, no different

    Is it higher??

    © BrainMass Inc. brainmass.com December 24, 2021, 6:50 pm ad1c9bdddf

    Solution Preview

    To answer this question, we need to know what pKa means.

    pKa = -log Ka

    So, what does that tell us? What is Ka? That is the dissociation or ionization constant for an acid.

    HA + H2O <------> A- + H3O+

    Ka = [A-][H3O+]/[HA]

    Therefore, the more that the acid dissociates in water, the larger the Ka. The Ka is a measure of the degree of ionization of an acid in water. A ...

    Solution Summary

    The expert examines Pka histidine protein active site.