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    Collagen Role and Structure

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    In your paper, address the following points:

    Explain why Glycine, which appears quite frequently, is important to the helical structure of collagen?
    Compare the structure of collagen to the twisted fibers in a rope.
    Explain how mutations in cases of Osteogenesis imperfecta result in more brittle bones.
    If a bulkier amino acid is substituted for the glycine residues in the collagen sequence, what is the impact on the collagen triple helix?
    Have you ever noticed that meat from an older animal is tougher? Consider what happens to collagen molecules as they age. Collagen can be intermolecularly and intramolecularly crosslinked. This covalent bond occurs between Lysine and Histidine side chains. Explain how this modification leads to increased stiffness and a decrease in tensile strength.
    please make each question a page and references please.
    Submitting Your Work.

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    Solution Preview

    See attachments.

    Let's divide questions into points :
    1- Collagen
    what is collagen?, it is insoluble fibrous protein of the extracellular matrix (ECM) of connective tissue (pic1), what is the basic structure of collagen?, it is triple-stranded helical structure composed of three polypeptide chains (α-chains) and pack together to form long thin fibrils arranged in bundles (Pic2), then you may mention types of collagen and the difference in structure (arrangement of the three polypeptides chain) between these types. [1]

    2- Amino acids of the polypeptide chain
    The basic amino acid motif is Gly-Pro-X, X can be any amino acid, such as Hydroxyproline[1]

    3- Glycine
    Glycine helps hold the three ...

    Solution Summary

    This solution of 367 words discusses the role and structure of collagen. It also explores the real-life application of collagen in different examples.