Although coenzymes seem autonomous in there catalytic structure they have no catalytic powers when not bound to an enzyme-why?
Coenzymes work in conjunction with the enzymes to which they are attached. In fact, coenyzmes are rather generic molecules that function with all sorts of different enzymes. Think of them as "plug in adapters." In and of themselves, they're kind of useless, but plug them in to the appropriate enzyme, and now, they can do their stuff -- but not on their own, rather in harmony with and using the amino acid residues in the enzyme itself. This is true whether we speak ...
A detailed written solution on on why coenzymes seem autonomous in the catalytic structure that have no catalytic powers when not bounded to an enzyme.