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Cellular origin of CO2

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Please explain the cellular origin of CO2 and need for O2 during human respiration.

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CO2 is generated in several steps:
1) when pyruvate is converted to acetyl-Co-A before acetyl-Co-A enters the citric acid cycle
2) when amino acids are converted to acetyl-Co-A before acetyl-Co-A enters the citric acid ...

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