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ADME, or the four phases of toxic compound disposition; DDT

The four phases of the disposition of a toxic compound to assess its toxicity are absorption through membranes in a system, the distribution throughout the system, the excretion and elimination from the system and lastly, the metabolic fate of the chemical. Using these four phases assess the toxicity on DDT. I would also like to know how DDT is transported through the cell membranes. Is it passive diffusion, facilitated diffusion, filtration, active transport, etc. I know it is lipid soluble.

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Absorption

DDT is able to enter the body through a variety of means. These include lung and skin exposure; however, the insoluble nature of DDT means when it comes in contact with these tissues it will exist as crystals that are often too large to pass through the barrier membranes. Thus, these routes of administration are minor causes of exposure. The main route of absorption into the body by far is ingestion. Serum concentrations of DDT increase significantly and are the highest when DDT is consumed in the diet. In addition, the absorption of DDT can be significantly raised if it is first dissolved in edible oils (raising the absorbance to approximately 70-90% of the entire dose). This gives evidence for the non-polar, water insoluble nature of DDT, suggesting that its main route of cellular entry is through passive ...

Solution Summary

With respect to DDT, the four phases of disposition are explored in a brief essay. Do you know your four phases of disposition in pharmacology? You'll find out in this solution!

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