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Studies involving Animals

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There are a variety of animal models of stroke and resultant memory disorders. Many types of neurological disorder and brain damage can produce memory impairments in humans, and it has been possible to model some of these in animals.

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Animal research has many practical applications to the study and treatment of the human brain.

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Animal research has many practical applications to the study and treatment of the human brain. Many types of neurological disorder and brain damage can produce memory impairments in humans, and it has been possible to model some of these in animals. The first successful attempt at this was production of an animal model of brain-damaged-induced amnesia. It had been known since the 1950's that damage to the temporal lobes, as a result of disease, traumatic injury, epilepsy, or infection, could produce a disorder known as anterograde amnesia, the inability to form new long-term memories. This is in contrast to the better-known retrograde amnesia, which is an inability to remember previously stored information.

Beginning in the late 1970's, work with monkeys, and later rats, began to identify the critical temporal lobe structures that, when damaged, produce anterograde amnesia. These structures include the hippocampus and, perhaps more important, the adjacent, overlying cortex, which is known as the rhinal cortex. As a result of this work, this ...

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