I am trying to answer a study question for my toxicolgy class but cannot find any reference to the question in the texts. The question reads:
A low protein diet can result in increased blood levels of cadmium and lead. Propse a reason for this effect and describe the mechanism(s)that would be involved in causing this observed response.© BrainMass Inc. brainmass.com October 16, 2018, 9:33 pm ad1c9bdddf
This is a very interesting question. The link between low-protein diets and increased susceptibility to cadmium toxicity has been know since the 1970's. A quick search at pubmed.com using the keywords low-protein diet and cadmium will bring back many current research papers on the subject. To get to the heart of why low-protein diets lead to cadmium absorption we must first look at the minerals involved. Cadmium, Lead, Zinc, Calcium and Iron are among several divalent metal cations (metal ion with 2 less electrons; 2+). While iron, zinc and calcium are needed for normal ...
Detailed paragraph and web references examining the link between low protein diets and cadmium and lead poisoning.
Inorganic and Organometallic Contaminants
1. Provide three reasons for children's high susceptibility to lead (Pb) toxicity, when compared with adults.
2. Current reference dose for oral exposure to methylmercury is 0.1 ug/kg of body weight (U.S. EPA, February 2004). For a woman of 60 Kg, the reference dose is equivalent to ingesting 6.0 ug per day. Question: Based on the median concentrations of Hg in the aquatic species in Table H (see below), assuming 90% of the Hg is methylmercury, which of the items the woman can consume in the amount of 0.25 kg per day to keep the exposure below 6.0 ug/day?
3. Is trimming off skin and fat of methylmercury contaminated fish an effective method to decrease exposure? Please explain your answer.
4. Identify the susceptible populations of arsenic toxicity.
5. Identify the susceptible populations of cadmium toxicity.