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Cause and effect relationship of disease clusters

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Disease clusters indicate a cause and effect relationship. Please help explain why this is true. Please give an example of one disease with an established connection and one example of a disease with only an associated risk factor currently known. What are some key differences between the concepts of causation and association with an illustrative example. Please list references.

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The cause and effect of the risk factors of smoking on lung cancer, COPD and heart disease.

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cause and effect of disease clusters
Disease clusters indicate a cause and effect relationship. Need help explaining why this is true. Please give an example of one disease with an established connection and one example of a disease with only an associated risk factor currently known. What are some key differences between the concepts of causation and association with an illustrative example. ...

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