Evaluating Receptor/Ligand Binding
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3. Evaluating Receptor/Ligand Binding as a Reversible Mixed Second-Order Reaction
The solutions for reversible binding between receptors and ligands to form complexes,
R + L C, when ligand is in excess are:
where the equilibrium dissociation constant and relaxation time are defined as
and , respectively.
a. Sketch qualitatively a plot of [C] vs. t for [C]o < [C]eq.
b. describe the effect of increasing total ligand concentration, [L]T, on the dynamic and equilibrium behavior of the system.
c. describe the effect of decreasing the equilibrium dissociation constant on the dynamic and equilibrium behavior of the system. What kinetic property must change and how if the equilibrium dissociation constant is decreased while the reverse rate constant is not changed?
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Solution Summary
Here the provided equations are used to analyze the bonding behavior and question b) and c) are answered in detail. A plot to question a) is not provided. A qualitatively plot is sketched for [C] vs. t for [C]o < [C]eq.
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3. Evaluating Receptor/Ligand Binding as a Reversible Mixed Second-Order Reaction
The solutions for reversible binding between receptors and ligands to form complexes,
R + L C, when ligand is in excess are:
where the equilibrium dissociation constant and relaxation time are defined as
and , respectively.
a. Sketch qualitatively a plot of [C] vs. t for [C]o < [C]eq.
As I said in my message, I am not sure about this, but allow me to speculate: Were you discussing this in the context of NMR? This is really the only technique/context I can think of were one would talk about a relaxation time. ...
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