Human growth hormone binds to a cell surface membrane protein that is not a receptor tyrosine kinase. The intracellular domain of the receptor can bind other proteins inside the cell. Furthermore, studies indicate that the receptor is monomeric in the absence of hormone but dimerizes on hormone binding. Propose a possible mechanism for growth hormone signaling.© BrainMass Inc. brainmass.com October 24, 2018, 9:24 pm ad1c9bdddf
Receptor dimerization is a common mechanism used in signaling cascades. The presentation of the ligand binds to the cell ...
Short paragraph and reference examining the importance of receptor dimerization in growth hormon signaling.
Cell Surface Receptor and Rapid Signalling
If cell surface receptors can rapidly signal to the nucleus by activating latent gene regulatory proteins such as STAT's at the plasma membrane, why do most cell cell surface receptors use long, indirect signaling cascades to influence gene transcription in the nucleus?View Full Posting Details