Human growth hormone binds to a cell surface membrane protein that is not a receptor tyrosine kinase. The intracellular domain of the receptor can bind other proteins inside the cell. Furthermore, studies indicate that the receptor is monomeric in the absence of hormone but dimerizes on hormone binding. Propose a possible mechanism for growth hormone signaling.
Receptor dimerization is a common mechanism used in signaling cascades. The presentation of the ligand binds to the cell ...
Short paragraph and reference examining the importance of receptor dimerization in growth hormon signaling.