Organic Chemistry Questions on Nucleophilic Substitution
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Questions:
1. In the purification process, the organic layer is washed sequentially with 2 M NaOH, water, and saturated aqueous sodium chloride. What is the purpose of each of these washes and why is cold 2 M NaOH recommended?
2. How would doubling the concentration of the nucleophile affect the rate of an SN2 reaction?
3. Specify the most electrophilic carbon atom in 1-butanol and rationalize your choice.
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1. NaOH is used usually to remove any acid formed. HBr could form which will then be neutralized by NaOH. Cold solutions are ...
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