Describe the mechanism of aromatic substitution in anisole
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Write down the mechanism of nitration of anisole along with the sigma complex intermediate for ortho, meta, para nitration.
By using sulfuric acid with nitric acid to form the nitronium ion electrophile derive the mechanism of reaction.
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Solution Summary
By using sulfuric acid with nitric acid to form the nitronium ion electrophile we have the mechanism of reaction.
NO2+ forms a sigma complex with benzene or substituted benzene (here anisole), and loses H+ to form nitrocompound
? Remember that alkyl groups stabilize the sigma complex by induction, donating electron density through the sigma bond.
? Substituents with a lone pair of electrons like -OCH3 stabilize the sigma complex by resonance
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Attachment of an electrophile ortho or para to them leads to a more stable complex because of resonance involving the electrondonating ...
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