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Synthesis Questions

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Can you please explain these problems. See the attached file.

1.) Which form of molecule A is the most stable (1, 2, or 3)? Provide a graphical (i.e. figures not graphs) provide an explanation for your answer.

2.) Enamines are generally reactive toward electrophiles. For example, compound E reacts with HBr at room temperature. Surprisingly, enamine F is unreactive with HBr even at 150 °C. Provide a rationale for this difference in reactivity.

3.) The cis isomer of 1,2-azodifluoride (below) is more stable than the trans isomer by 3 kcal/mol. Explain this difference.

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See the attached file(s).

1.) Which form of molecule A is the most stable (1, 2, or 3)? Provide a graphical (i.e. figures not graphs) provide an explanation for your answer.

Check this website, I'll be glad to update the posting with more explanations if you are not sure about what the interactions are.

http://www2.trincoll.edu/~tmitzel/advorgfold/probsetfold/ps_2/ps_2_ans/ps_2_ans.htm

2.) Enamines are generally ...

Solution Summary

The molecules which are the most stable are given. Enamines that are reactive towards electrophiles are also discussed. The differences in reactivity are provided.

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