The typical length of a DNA strand is 3.4cm. In order to fit into a cell, the DNA strand is supercoiled around proteins called histones. Histones are a family of five proteins thet are rich in the amino acids and lysine. How do histones stabilize the DNA strand? (look at the backbone of the DNA strand at the molecular level.)
The deoxyribose sugar-phosphate backbone of the DNA molecule is negatively charged due to all of the phosphate groups. Histones are basic proteins (as opposed to acidic proteins) with lots of positive charges due to a high proportion ...
It explains how histones stabilize the DNA strand. It also explains the mutation in DNA.