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Discuss the metabolic requirements for growth of each microbe and select one antibiotic (bacteria), antiviral (virus) or anti-fungal (fungi) agent, depending on the pathogens that you selected. Discuss the mechanism of action by which the drug kills or inhibits the growth of the selected pathogen.
Be sure to look on your library bookshelf for many useful books that will help you begin your research! Try A Concise Manual of Pathogenic Microbiology, Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance, and Clinical Applications, and/or Fungal Infection: Diagnosis and Management to begin your research.
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Many microbes are pathogenic and can cause many devastating diseases. The battle between the hosts and microbes for survival is never ending. The host-microbes interaction is very complex. To fight the microbial diseases, we need to develop antimicrobial agents that would suppress the growth of microbes in the future. These antimicrobial agents include antibacterial agents, antiviral agents, and anti-fungal agents.
The requirements for bacterial growth includes many factors. These sources of factors are carbon sources (sugar and fatty acids), metal ions, iron, optimal temperature, pH, and oxygen.
Bacteria that are obligate aerobes must have oxygen to grow. Obligate anaerobe do not need oxygen for growth and are killed by oxygen. Facultative anaerobes can do both fermentation and aerobic respiration.
Microbes also require nutrient for growth. The nutrients include organic carbon, nitrogen, phosphorus, sulfur and metal ions. Microbes secrete small molecule that bind iron. Bacteria are actively compete with host for iron.
Microbes can grow at all kinds of temperature from freezing to boiling point. The best growth bacteria are called mesophiles that include pathogens and opportunists.
Many bacteria grow best at neutral pH and can survive in acid ...
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