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    Reactions: Inhibit, Catalyse and Glycolosis

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    Why is it advantageous for citrate, the product of reaction 1 of the TCA, to inhibit phosphofructokinase, which catalyses the third reaction in glycolysis?

    © BrainMass Inc. brainmass.com October 9, 2019, 4:38 pm ad1c9bdddf
    https://brainmass.com/biology/metabolism/reactions-inhibit-catalyse-glycolosis-37446

    Solution Preview

    Below are the advantages of citrate inhibition of phosphofructokinase:

    1. Regulation of Glycolysis:
    Glycolysis is regulated by changes in the catalytic activity of the glycolytic enzyme phosphofructokinase. Accumulation of the allosteric activator ADP causes ADP to be bound to an allosteric site on this enzyme, ...

    Solution Summary

    The solution discusses why it is advantageous for citrate, the product of reaction 1 of the TCA, to inhibit phophofructokinase, which catalyses the third reaction in glycolysis.

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