Why is it advantageous for citrate, the product of reaction 1 of the TCA, to inhibit phosphofructokinase, which catalyses the third reaction in glycolysis?
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Below are the advantages of citrate inhibition of phosphofructokinase:
1. Regulation of Glycolysis:
Glycolysis is regulated by changes in the catalytic activity of the glycolytic enzyme phosphofructokinase. Accumulation of the allosteric activator ADP causes ADP to be bound to an allosteric site on ...