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Peptidoglycan detection

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What is meant by "detection of peptidoglycan by the host requires prior processing?"

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https://brainmass.com/biology/human-biology/peptidoglycan-detection-148386

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Peptidoglycans are a combination of amino acids (peptid-) and sugars (glycans) on the surface of bacteria. They are more abundant on the surface of gram positive than gram negative bacteria. When a bacteria ...

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Short paragraph with web references examining the detection of peptidoglycans.

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