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Mark and Dave are hiking. The hikers surprise a mother bear and her two cubs on the trail. The mother bear makes it clear about being unhappy that she was surprised by the two hikers. Mark is taking a medication that specifically blocks muscarinic acetylcholine receptors and Dave is taking a medication that specifically blocks nicotinic acetylcholine receptors. How would the effects differ between the drug that blocks muscarinic acetylcholine receptors and the drug that blocks nicotinic acetylcholine receptors in terms of the physiological response Mark and Dave are likely to experience when they encounter the angry mother bear and her two cubs?

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Nicotinic ACh receptors are found in the autonomic nervous system as well as in skeletal muscle. Muscarinic ACh (mACh) receptors are found only in the autonomic nervous system. In the autonomic nervous system, mACh receptors can be found in the parasympthetic system where they upregulate the parasympathetic nervous system, thereby decreasing the fight or light ...

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The expert examines acetylcholine mother bear experience is examined.

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We conducted a laboratory practical in aim to investigate the action of the neurotransmitters acetylcholine and noradrenaline on mammalian gut motility. Upon addition of either of the two drugs we recorded the rhythmic contractions generated by the basic electric rhythm. by plotting the results I was able to draw a sigmoidal curve; also I was able to identify that acetylcholine has a depolarising action where as noradrenaline hyperpolarising however I am unsure on why the sigmoidal curve was produced and also what the effects of INCREASING the concentrations of each drug on the tonic tension of the smooth gut muscle are along with the effects on rate and amplitude of rhythmic contractions.

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