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    Genetics

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    Describe a single gene inherited disease, a multi-factorial (multiple genes and
    environmental factors) disease, and non-inherited genetic disease. Use Down syndrome, sickle-cell anemia, asthma and breast cancer as examples

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    Genetic disease:

    A disease caused by an abnormality in an individual's genome. There are a number of different types of genetic inheritance:

    Single gene inheritance -- Also called Mendelian or monogenic inheritance. This type of inheritance is caused by changes or mutations that occur in the DNA sequence of a single gene. There are more than 6,000 known single-gene disorders, which occur in about 1 out of every 200 births. Some examples are cystic fibrosis, sickle cell anemia, asthma, Marfan syndrome, Huntington's disease, and hemochromatosis. Single-gene disorders are inherited in recognizable patterns: autosomal dominant, autosomal ...

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